Principal Investigator

Allon Klein

Associate professor of Systems Biology, Harvard Medical School

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Throughout Dr. Allon Klein’s career, he has been interested in how cells make decisions. This is a multi-scale problem, with explanations spanning from identifying ‘molecular instabilities’ that drive regulatory networks to one of several stable states, to defining interactions across tissues and even organisms. Understanding cellular decision-making also requires determining how cells and tissues maintain discrete phenotypes over many years of life. These problems cannot be solved using any single discipline. Dr. Klein worked on these problems first as a statistical physicist in his PhD with Dr. Ben Simons (Cambridge), before transitioning into experimental biology and computational genomics during a postdoc with Dr. Marc Kirschner. To address these general questions, the Klein lab develops new assays, technologies and theoretical methods.

Email: allon_klein AT hms.harvard.edu

Current Members

Postdoctoral researchers

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Charlotte Strandkvist

Postdoctoral Research Fellow
As a postdoc, Charlotte is working with the Klein lab and the Paulsson lab to understand cellular decision making, particularly how transcriptional heterogeneity relates to cell fate. Before embarking on experiments, Charlotte was a theorist working on applying methods from statistical physics, stochastic processes and probability theory to problems in biology. She loves to collaborate and talk science over a cup of coffee.

Email: charlotte_strandkvist AT hms.harvard.edu

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Laura Bagamery

Postdoctoral Research Fellow
Laura received her PhD in molecular and cellular biology from Harvard University, where she studied glucose metabolism and mitochondrial network topology in budding yeast. She’s interested in non-genetic cell heterogeneity, the evolutionary pressures that shape tissue-specific gene expression, and cats.

Email: bagamery AT fas.harvard.edu

Sean McGeary

Postdoctoral Research Fellow
Sean received his PhD under Dr. David Bartel at MIT, where he developed high-throughput biochemical assays to better understand the quantitative effects of miRNAs on their target mRNAs in cells. Sean studies molecular mechanisms by which regulated gene expression mediates cellular processes, with an interest in developing novel experimental and analytical approaches. Outside of the lab, Sean enjoys music and film.

Email: sean_mcgeary AT hms.harvard.edu

JAMES Taggart

Postdoctoral Research Fellow
Email: james_taggart AT hms.harvard.edu

 

Graduate students

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Kalki Kukreja

PhD student
Kalki did her undergrad in Biochemical Engineering and Biotechnology from IIT Delhi. She is studying cell cycle dynamics in embryonic development using Zebrafish as a model system. Outside research, Kalki enjoy music and dancing on Bollywood beats.

Email: kalki_kukreja AT g.harvard.edu

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Qiu Wu

PhD student
Qiu studied Cell Biology and Biochemistry in college. She is interested in extracellular signaling regulation in the context of cell fate decisions. On weekends she likes to go hiking and play with her cat named Australopithecus or Lucy for short.

Email: q_wu AT g.harvard.edu

Tal Deborah Scully

PhD student
Tal went to MIT for undergrad, where she studied physics and theater. She is studying the evolution of red blood cells, for which she works with Ciona robusta, a bizarre animal which she has grown quite fond of. Outside the lab, Tal enjoys flute, Dungeons & Dragons, and bioethics.

Email: talscully AT fas.harvard.edu

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Nicolas Gort Freitas

PhD student
Nico studied biology and data science at Minerva, a traveling university that allowed him to live in six countries throughout his undergrad studies. In the Klein lab, he studies variability in human hematopoiesis. In his free time, Nico sings at the Longwood Chorus and plays soccer. He also enjoys dancing, doing anything outdoors, and making high-quality memes.

Email: ngortfreitas AT g.harvard.edu

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IGNAS MAZELIS

PhD student Fascinated by droplets and trained as a biochemist with Microfluidics and Synthetic biology background, Ignas is mostly focused on expanding the single-cell analysis toolkit. While not encapsulating things, He enjoys rock climbing, running, and hiking.

Email: ignas_mazelis AT g.harvard.edu

Yuyang chen

PhD student

Yuyang went to Peking University for undergrad, where obtained a Bachelor's degree in Basic Medical Sciences and Physics. In the lab, he tracks single cells to study cell differentiation. Outside the lab, Yuyang enjoys playing sports and watching Arsenal games.

Email: yuyang_chen AT fas.harvard.edu

Research staff

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Mandovi Chatterjee

Single Cell Technology Manager,
Director, Single Cell Core at Harvard Medical School
Mandovi received her PhD in Cell Biology from University of Virginia, where she worked on nucleocytoplasmic transport of protein. In the Klein lab she is interested in developing new and existing technology in the field of single cell biology. When not in lab, she likes to travel, learn about nature and history, and spend time with her family.

Email: mandovi_chatterjee AT hms.harvard.edu

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LEXIE OBRIEN

Research Associate

Lexie is from Des Moines Iowa. She graduated with her bachelors in microbiology from Iowa state university this year. Lexie hopes to eventually go to grad school and get her PhD in microbiology as well.

Email: lexie_obrien AT hms.harvard.edu

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Daisy Alice Correia

Executive Coordinator

Email: daisy_correia AT hms.harvard.edu

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Will Ye

Lab Manager
After receiving his Biology degree from Tufts University, Will worked in zoos and aquariums caring for a variety of animals including octopuses, alligators, and lemurs. Most recently, Will managed an axolotl colony for a limb regeneration lab at Harvard University. In his free time, he likes to spend as much time as possible outdoors playing basketball, grilling for friends, and hiking. When the weather does not cooperate, he enjoys drawing and cooking.

Email: will_ye AT hms.harvard.edu

Former lab members

(Latest to earliest)

PhD students

Hailey Cambra
Vertex Fellow, Vertex Pharmaceuticals

Samuel Wolock
Senior scientist, Dyno Therapeutics

Naren Tallapragada
Technology Resident, X, the Moonshot Factory
Founder, Tessel Biosciences

Caleb Weinreb
Postdoctoral researcher, Harvard Medical School

James Briggs
Schmidt Science Fellow, Broad Institute

Other graduate students

Rapolas Zilionis
Former visiting Master’s student (Vilnius University)
Chief Scientific Officer, Droplet Genomics

Postdoctoral researchers

Shou-Wen Wang
Assistant professor, Westlake University

Daniel Montoro
Co-founder, stealth-state biotech company

Nikit Patel
Research scientist, K2 Biotech

Yuheng Lu

Katie McCauley
Principal investigator, Novartis

Dan Wagner
Assistant professor, UCSF

Kyogo Kawaguchi
Assistant professor, RIKEN Japan

Research staff

Ian Brenckle
Former research technician
Senior research associate, Dyno Therapeutics